1. COLECȚIA INSTITUȚIONALĂ: Recent submissions

  • Metabolic peculiarities of immunotherapeutic medicines (chimeric antigen receptor t cells) used in cancer treatment (b-cell acute lymphoblastic leukemia) 
    Sluchin, Andrei (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. In the dynamic realm of cancer therapeutics, many studies explore the metabolic nuances of Chimeric Antigen Receptor (CAR) T-cell therapy in treating B-cell acute lymphoblastic leukemia (B-ALL). Understanding ...
  • The interplay of growth hormone, insulin-like growth factors, and cancer susceptibility: a medical perspective 
    Briceag, Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. GH and IGF-I, known for promoting growth, are under scrutiny for their potential involvement in cancer progression. While we understand their normal effects, the disruption caused by these factors and their ...
  • Biochemical aspects of heart diseases in patients with diabetes mellitus 
    Parapuravalappil Sathyan, Krishnadas (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The prevalence of diabetes mellitus is continuously increasing globally and is estimated to reach approx. 366 million by 2030. According to the latest research, the cardiovascular changes due to diabetes are ...
  • Biochemical changes of the vascular endothelium in diabetic pathology 
    Stici, Vlada (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Diabetes mellitus (DM) is a multifactorial pathology that has become a worldwide problem due to its rapid spread and progression. Persistent hyperglycemia in DM induces disruption of vascular homeostasis by ...
  • The role of leptin in the pathogenesis of metabolic dysfunction-associated fatty liver disease 
    Darii, Felicia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has become one of the leading causes of end-stage liver disease. Its pathogenesis is not fully understood, but leptin may contribute to the development ...
  • Psycho-emotional state before and after the injectable procedure 
    Cazacu, Victoria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Persons who would like a change of the exterior, including those who are often afraid to start the aesthetic intervention for reasons when they want to stop the procedure, will look worse or are afraid of the ...
  • Disruption of the immune response in patients with obesity during COVID-19 
    Zahlîstnîi, Bogdan (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Obesity was one of the frequent comorbidities in hospitalized patients with SARSCoV-2 infection. The recent studies of Covid-19 outcomes have noticed a correlation between obesity and more severe clinical ...
  • GLUTs genetic defects as causes of diabetes 
    Ciuchitu, Alina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Diabetes mellitus (DM) is a chronic disease marked by insulin secretion or action defects. The cause of diabetes can be genetic defects of glucose transporters – GLUT, the most characteristic being the GLUT2 ...
  • Impact of chronic obstructive pulmonary disease on quality of life 
    Lupu, Liliana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Chronic Obstructive Pulmonary Disease (COPD) is the leading cause of morbidity and mortality worldwide. According to the World Health Organization, globally, COPD is the third leading cause of death, accounting ...
  • Pulmonary tuberculosis with pneumonia-like onset in post-pandemic era: case series 
    Potop-Rotari, Dorina; Amoașii, Anastasia; Hapun, Diana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Outbreak of pulmonary tuberculosis (TB) in post-COVID-19 era represents a real medical and social problem. It remains a diagnostic challenge due to a variety of respiratory (pneumonia, malignancy etc.) and ...
  • Kidney damage in gout patients 
    Cornea, Cornelia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. In patients who have suffered from gouty arthritis for many years, renal cone disease is very common. After arthritis, the most common clinical manifestation of hyperuricemia is renal interest. Aim of study. ...
  • Clinical and serological expressions of SLE among patients from Republic of Moldova and India 
    Sethi, Vansh (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may affect all systems and presents with a broad spectrum of immune abnormalities. The skin is the second organ in terms of frequency ...
  • Hypereosinophilic syndrome - diagnostic challenges in allergic patients 
    Chiosa, Mihaela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Eosinophilia is a common laboratory manifestation associated with multiple diseases (allergic, parasitic, infectious or oncological diseases). Eosinophilia is an increase in the absolute values of eosinophils ...
  • The role of systematic screening in the detection of pulmonary tuberculosis in diabetic patients 
    Gumeniuc, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The burden of diabetes mellitus (DM) is increasing globally. The association between DM and tuberculosis (TB) is the next challenge for TB control worldwide. DM and TB represent a mutually disadvantageous ...
  • Post-COVID-19 sequelae 
    Focsa, Nicoleta (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. COVID-19 is a pandemic infection caused by the novel severe acute respiratory syndrome coronavirus-2, affecting millions of people worldwide and having devastating consequences on health systems, the economy, ...
  • Diagnostic accuracy of Xpert Ultra for microbiological confirmation of pulmonary tuberculosis in patients with paucibacillary disease 
    Sîrbu, Vasile (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Worldwide, up to one-third of pulmonary tuberculosis patients are missed for microbiological confirmation. Assessment of specimens obtained during bronchoscopy is one of the well-recognized methods that can ...
  • Sarcoidosis and tuberculosis- a diagnostic and management challenge 
    Noureen, Ali (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The intricate relationship between sarcoidosis and tuberculosis has been a subject of considerable debate among clinicians and researchers as both diseases exhibit clear clinical parallels that make differential ...
  • Molecular aspects of aminoglycoside ototoxicity 
    Cojevnicov, Emanuela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Aminoglycosides are a class of antibiotics widely used in pediatric clinical practice due to their effectiveness against gram-negative bacterial infections. Despite this, they are known to have cochleotoxicity ...
  • Epidemiology and clinic-paraclinic features of osteoporosis in men 
    Abu Hussen, Abd El Rahim (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Osteoporosis is the disease of bone tissue and it is not limited to postmenopausal women. In recent decades, increasing attention has been paid to osteoporosis in older men. It has been established that men ...
  • Clinical features of Epstein-Barr virus infection in children aged 0-3 years 
    Vlad, Vasile (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Epstein-Barr virus (EBV), or human herpesvirus 4, is a gammaherpesvirus that infects more than 95% of the world's population, most commonly manifesting itself through acute infectious mononucleosis, frequently ...

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