1. COLECȚIA INSTITUȚIONALĂ: Recent submissions

  • Evaluation of adiposity indices in pediatric rheumatological disorders 
    Cepraga, Victoria; Nedealcova, Elena (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The Body Mass Index (BMI) is currently the most used indicator that assesses the nutritional status of children and adults, but it cannot fully reflect the difference between excess adipose tissue and that ...
  • Emicizumab in pediatric hemophilia a: a case study 
    Miaun, Livia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The development of inhibitors that neutralize the function of clotting factor VIII is currently the most challenging complication associated with the hemophilia A treatment. Emicizumab is a humanized bispecific ...
  • Cardiovascular damage in children with systemic lupus erythematosus 
    Muringakodan, Najmulhudha (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Juvenile Systemic Lupus Erythematosus (jSLE) is a rare autoimmune disorder affecting multiple systems in children and adolescents causing unique challenges in diagnosis and management. Cardiovascular ...
  • Microscopic and ultrastructural characteristics of keratinocytes 
    Coltuc, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Keratinocytes are the principal epidermal cells, constituting the outermost layer of the skin - the external and largest organ of the human body. Epidermal keratinocytes are highly specialized epithelial cells ...
  • Etiology, pathogenesis, diagnosis and treatment of ovarian cancer 
    Cheacir, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The 5th most common cause of death among women is caused by ovarian cancer. According to the American Cancer Society, the risk of being diagnosed with ovarian cancer throughout life for women is 1 in 78. In ...
  • Parents' knowledge, attitudes and practices regarding infant feeding 
    Pirlii Mihaela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Adequate nutrition in the first year of life is an essential condition for the healthy growth and development of a child. According to periodic studies in the field, there are variable but constant deficiencies ...
  • Paroxysmal supraventricular tachycardia in children 
    Haled, Garah (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Supraventricular tachycardia is an abnormally rapid heartbeat. SVT is the most prevalent rhythm irregularity. According to estimates, it can happen to up to 1 in 250 otherwise healthy kids. Episodes are ...
  • Exploring the role of N-terminal pro-brain natriuretic peptide as a diagnostic biomarker in Kawasaki disease 
    Duca, Alexandra (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is an acute febrile illness of unknown cause that stands out as a unique and challenging pediatric vasculitis, characterized by acute ...
  • Metabolic peculiarities of immunotherapeutic medicines (chimeric antigen receptor t cells) used in cancer treatment (b-cell acute lymphoblastic leukemia) 
    Sluchin, Andrei (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. In the dynamic realm of cancer therapeutics, many studies explore the metabolic nuances of Chimeric Antigen Receptor (CAR) T-cell therapy in treating B-cell acute lymphoblastic leukemia (B-ALL). Understanding ...
  • The interplay of growth hormone, insulin-like growth factors, and cancer susceptibility: a medical perspective 
    Briceag, Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. GH and IGF-I, known for promoting growth, are under scrutiny for their potential involvement in cancer progression. While we understand their normal effects, the disruption caused by these factors and their ...
  • Variation of the mastoid segment of the facial canal and of the stylomastoid foramen 
    Ashkar, Laila (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Taking into consideration that the ratio of the facial nerve iatrogenic injuries in primary mastoidectomy is 0.6%-3.7%, and a twice higher ratio of 4%-10% is reported for the revision surgery, the knowledge ...
  • Biochemical aspects of heart diseases in patients with diabetes mellitus 
    Parapuravalappil Sathyan, Krishnadas (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The prevalence of diabetes mellitus is continuously increasing globally and is estimated to reach approx. 366 million by 2030. According to the latest research, the cardiovascular changes due to diabetes are ...
  • Biochemical changes of the vascular endothelium in diabetic pathology 
    Stici, Vlada (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Diabetes mellitus (DM) is a multifactorial pathology that has become a worldwide problem due to its rapid spread and progression. Persistent hyperglycemia in DM induces disruption of vascular homeostasis by ...
  • The role of leptin in the pathogenesis of metabolic dysfunction-associated fatty liver disease 
    Darii, Felicia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has become one of the leading causes of end-stage liver disease. Its pathogenesis is not fully understood, but leptin may contribute to the development ...
  • Disruption of the immune response in patients with obesity during COVID-19 
    Zahlîstnîi, Bogdan (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Obesity was one of the frequent comorbidities in hospitalized patients with SARSCoV-2 infection. The recent studies of Covid-19 outcomes have noticed a correlation between obesity and more severe clinical ...
  • GLUTs genetic defects as causes of diabetes 
    Ciuchitu, Alina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Diabetes mellitus (DM) is a chronic disease marked by insulin secretion or action defects. The cause of diabetes can be genetic defects of glucose transporters – GLUT, the most characteristic being the GLUT2 ...
  • Treatment of acute non-lymphoblastic leukemias 
    Pusca, Adelina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Acute myeloid leukemias (AML) are a group of hematological malignancies with primary involvement of the bone marrow (BM). These disorders of hematopoietic system develop due to genetic changes in blood cell ...
  • Clinical ”Odyssey” in Wilson's disease patients from the Republic of Moldova 
    Cumpătă, Veronica (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Wilson's disease (WD) presents high clinical heterogeneity, independent of age and sex. In our country, it is the first study that analyzes the phenotype of patients with this genetic disorder. Aim of study. ...
  • Clinical and hematological features and diagnostic options in extranodal aggressive non-Hodgkin's lymphomas 
    Pîrlii, Iulius (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Lymphomas can be simply defined as malignant neoplasms of lymphocytes and their precursor cells. Common sites of extranodal manifestations are the gastrointestinal tract, especially the ventricle, pharynx, ...
  • The influence of obesity on the quality of life in patients with gastro-esophageal reflux disease 
    Stoica, Mihaela; Munteanu, Ecaterina; Neagu, Stepan; Sârbu, Oxana; Calin, Ghenadie; Scurtu, Alina; Scorpan, Anatolie (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Obesity or exaggerated growth of adipose tissue according to body mass index (BMI) has shown an increase in the prevalence of gastroesophageal reflux disease (GERD), which significantly affects the quality ...

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