MedEspera 2024: Recent submissions

  • Emicizumab in pediatric hemophilia a: a case study 
    Miaun, Livia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The development of inhibitors that neutralize the function of clotting factor VIII is currently the most challenging complication associated with the hemophilia A treatment. Emicizumab is a humanized bispecific ...
  • Cardiovascular damage in children with systemic lupus erythematosus 
    Muringakodan, Najmulhudha (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Juvenile Systemic Lupus Erythematosus (jSLE) is a rare autoimmune disorder affecting multiple systems in children and adolescents causing unique challenges in diagnosis and management. Cardiovascular ...
  • Microscopic and ultrastructural characteristics of keratinocytes 
    Coltuc, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Keratinocytes are the principal epidermal cells, constituting the outermost layer of the skin - the external and largest organ of the human body. Epidermal keratinocytes are highly specialized epithelial cells ...
  • Etiology, pathogenesis, diagnosis and treatment of ovarian cancer 
    Cheacir, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The 5th most common cause of death among women is caused by ovarian cancer. According to the American Cancer Society, the risk of being diagnosed with ovarian cancer throughout life for women is 1 in 78. In ...
  • Parents' knowledge, attitudes and practices regarding infant feeding 
    Pirlii Mihaela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Adequate nutrition in the first year of life is an essential condition for the healthy growth and development of a child. According to periodic studies in the field, there are variable but constant deficiencies ...
  • Paroxysmal supraventricular tachycardia in children 
    Haled, Garah (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Supraventricular tachycardia is an abnormally rapid heartbeat. SVT is the most prevalent rhythm irregularity. According to estimates, it can happen to up to 1 in 250 otherwise healthy kids. Episodes are ...
  • Adeno-associated virus (AAV) - based gene therapies for retinal diseases 
    Ciolac, Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Retinal degeneration and macular dystrophies are the leading causes of visual acuity loss and blindness in middle-aged people worldwide. Existing treatment, although considered effective, often does not lead ...
  • Cystic fibrosis: current therapeutic targets based on symptoms occurred due to specific CFRT gene mutations 
    Caraman, Daniela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Cystic fibrosis (henceforth CF) is autosomal recessive disease involving mucus and sweat producing cells affecting multiple organs with lungs most severely affected leading to death in 90% of patients . A ...
  • Treatment of generalized nodal non-Hodgkin's lymphomas 
    Dunas, Adriana; Musteață, Vasile (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Non-Hodgkin's lymphomas (NHL) comprise a diverse group of malignant lymphoid tumors, with multiple distinct histological and immunohistochemical subtypes. Understanding and differentiating these subtypes is ...
  • Prevalence of POAF following cardiac surgery and comparative study on the preferred treatment modalities 
    Joy, Anugrah (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Postoperative atrial fibrillation (POAF) is a common arrhythmia after cardiac surgery, with an incidence ranging from 10-65%. It is more common in older patients and noncardiac surgery patients. POAF usually ...
  • The correct early diagnosis established by the multidisciplinary team is the key to success in the treatment of the post-myocardial infarction patient, complicated with renal infarction and pneumonia-infarction 
    Gobjila, Ion (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. According to the ESC guideline for the management of Acute Coronary Syndrome (ACS) it meets a spectrum of conditions, from symptoms and signs, with or without 12-lead ECG changes and with or without positive ...
  • The connection between the treatment of hypothyroidism with levothyroxine and its effects on the cardiovascular system 
    Ciorici, Daniela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Hypothyroidism is a common clinical condition. Thyroid hormones have multiple effects on the function of the cardiovascular system. Aim of study. Literature analysis to determine the relationship between ...
  • Epidemiological and clinical aspects of indolent extranodal non-Hodgkin's lymphoma in the Republic of Moldova 
    Josanu, Marina; Dudnic, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Non-Hodgkin's lymphoma (NHL)-lymphoproliferative tumors that are histologically and biologically heterogeneous. The most common subtypes of indolent NHL being follicular lymphoma (FL), marginal zone lymphoma ...
  • From oxidative stress to bone healing: a biochemical insight into the fracture recovery process 
    Dănilă, Alexandru (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Within bone tissue, osteoclasts release oxidative stress (OS) compounds, vital for calcified tissue breakdown and bone healing after fractures. However, imbalances between oxidant compounds like reactive ...
  • Nonalcoholic fatty liver disease pathogenic mechanisms and non-invasive diagnosis 
    Uncu, Ana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Non-alcoholic fatty liver disease (NAFLD) affects a quarter of the world's population and is one of the most common liver diseases. It can progress to liver cirrhosis and hepatocellular carcinoma (HCC). ...
  • Treatment of Hodgkin’s lymphoma in advanced stages 
    Marandici, Daniel; Musteață, Larisa; Musteață, Vasile (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Hodgkin's lymphoma is a relatively frequent neoplasm of the lymphatic system representing one of the most common types of cancer in young adults. Hodgkin's lymphoma is an aggressive, clinico-pathologically ...
  • Congenital anomalies in newborns: syndactyly 
    Zveaghinteva, Ludmila (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The name of “hand” comes from the Latin “manus”, derived from “manipulus”. The hand is the most perfected segment of the human locomotor system and is a complex organ made up of 27 bones, 27 joints and 19 ...
  • Hormonal disturbances in the polycystic ovary syndrome 
    Colin, Mihai; Stratulat, Silvia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Polycystic ovary syndrome (PCOS) is an endocrine pathology that affects women of reproductive age. Hormonal disturbances in the PCOS are the central cause of heterogenous clinical presentation involving ...
  • The clinical value of enthesitis in the early diagnosis of psoriatic arthritis 
    Melnic, Nicolae (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Joint diseases are one of the most common chronic diseases of society, and one of the most common is psoriatic arthritis (PsA), which is differentiated by a high incidence of enthesitis. Aim of study. ...
  • Kidney damage in gout patients 
    Cornea, Cornelia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. In patients who have suffered from gouty arthritis for many years, renal cone disease is very common. After arthritis, the most common clinical manifestation of hyperuricemia is renal interest. Aim of study. ...

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