MedEspera 2024: Recent submissions

  • The connection between the treatment of hypothyroidism with levothyroxine and its effects on the cardiovascular system 
    Ciorici, Daniela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Hypothyroidism is a common clinical condition. Thyroid hormones have multiple effects on the function of the cardiovascular system. Aim of study. Literature analysis to determine the relationship between ...
  • From oxidative stress to bone healing: a biochemical insight into the fracture recovery process 
    Dănilă, Alexandru (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Within bone tissue, osteoclasts release oxidative stress (OS) compounds, vital for calcified tissue breakdown and bone healing after fractures. However, imbalances between oxidant compounds like reactive ...
  • The involvement of micro-RNAs in cardiovascular pathologies 
    Bairamculov, Azamat (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Micro-RNAs are short molecules of ribonucleic acid with significant regulatory functions in controlling gene expression within eukaryotic cells. These small molecules play a crucial role in post-transcriptional ...
  • Nonalcoholic fatty liver disease pathogenic mechanisms and non-invasive diagnosis 
    Uncu, Ana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Non-alcoholic fatty liver disease (NAFLD) affects a quarter of the world's population and is one of the most common liver diseases. It can progress to liver cirrhosis and hepatocellular carcinoma (HCC). ...
  • Congenital anomalies in newborns: syndactyly 
    Zveaghinteva, Ludmila (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The name of “hand” comes from the Latin “manus”, derived from “manipulus”. The hand is the most perfected segment of the human locomotor system and is a complex organ made up of 27 bones, 27 joints and 19 ...
  • Hormonal disturbances in the polycystic ovary syndrome 
    Colin, Mihai; Stratulat, Silvia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Polycystic ovary syndrome (PCOS) is an endocrine pathology that affects women of reproductive age. Hormonal disturbances in the PCOS are the central cause of heterogenous clinical presentation involving ...
  • Unraveling the molecular signaling pathways in glial tumors with methylated MGMT promoters 
    Croitoru, Dan; Andronachi, Victor; Andrușca, Alexandru (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Most gliomas are typically assessed using imaging methods. A recent advancement in this regard involves the integration of biomarkers in conjunction with imaging techniques, such as 18F-FDG-PET-based radiomics ...
  • Role of mineralocorticoid receptor pathway in the pathogenesis of diabetic retinopathy 
    Toncoglaz, Alexandra (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Diabetic retinopathy (DR) represents a major cause of irreversible blindness among the working-age population. Aldosterone has an important role in the pathogenesis of DR, through vascular regulation, oxidative ...
  • Hereditary angioedema with C1 inhibitor deficiency 
    Butucel, Ana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Hereditary angioedema (HAE) is a rare autosomal dominant disease with deficiency or/and dysfunction of C1 inhibitor, caused by mutations in the C1-INH gene. HAE is characterized by potentially life-threatening ...
  • Cancer never takes a break — a new reality, the same relentless adversary 
    Luca, Ion (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Lung cancer presents a significant global health challenge, posing a pervasive threat to individuals worldwide. It stands as a major concern, often linked to severe prognoses and a substantial impact on quality ...
  • Portal hypertension: diagnosis and treatment management 
    Toha, Valeria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Portal hypertension is responsible for the more severe and even lethal complications of chronic liver disease and cirrhosis. Aim of study. Evaluation of the effect of ozone therapy on the state of circulation ...
  • Genetic variants of COMT gene expression and influence on pain perception 
    Crasevici, Irina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Catechol-O-methyltransferase (COMT) is a pivotal enzyme responsible for deactivating biologically active catechols, including crucial neurotransmitters such as dopamine, norepinephrine, and adrenaline. These ...
  • Dietary habits of patients with ischemic heart disease 
    Abraș, Tatiana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Ischemic heart disease continues to be the leading cause of mortality, morbidit y and high hospitalization rates in both high-income and developing countries. According to data from the World Health Organization, ...
  • Personalized medicine and cardiovascular diseases 
    Sooltan, Abdool Rahim (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. There was a remarkable growth in scientific publication on personalized medicine within the past few years in the field of cardiovascular disease. In the era of personalized/precision medicine the combination ...
  • External validation of a new prognostic score for mortality in the first 3 months of patients on the waiting list for liver transplantation 
    Pîrvu, Victor (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Viral liver cirrhosis is one of the most serious problems for the population due to its global spread, increased morbidity and mortality, and the high degree of disability caused by its rapid progression. Aim ...
  • Molecular aspects of aminoglycoside ototoxicity 
    Cojevnicov, Emanuela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Aminoglycosides are a class of antibiotics widely used in pediatric clinical practice due to their effectiveness against gram-negative bacterial infections. Despite this, they are known to have cochleotoxicity ...
  • Epidemiology and clinic-paraclinic features of osteoporosis in men 
    Abu Hussen, Abd El Rahim (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Osteoporosis is the disease of bone tissue and it is not limited to postmenopausal women. In recent decades, increasing attention has been paid to osteoporosis in older men. It has been established that men ...
  • Prevalence of anxious depressive syndrome in hospitalized in inflammatory arthritis 
    Manoharan, Ajitha Ancy (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Inflammatory arthritis is a chronic disorder that affects the joints. Inflammatory arthritis includes Rheumatoid arthritis, reactive arthritis, JIA, ankylosing spondylitis, etc. there have been studies that ...
  • Minimally invasive treatment of pituitary adenomas 
    Dumitrașco, Ana-Maria; Malai, Sergiu; Andrianova, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Pituitary adenomas (PAs) are among the most common tumors of the central nervous system, frequently diagnosed in the third and fourth decades of life. Despite their benign classification, PAs can result in ...
  • Teleneurology a 21st century challenge in monitoring chronic neurological conditions 
    Țîrchi, Daniela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Chronic neurological conditions, spanning neurodegenerative to autoimmune disorders, manifest prolonged and complex symptoms post-brain injuries. These challenges affect social interactions, career performance, ...

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