MedEspera 2024: Recent submissions

  • Indications and limits of gene therapy 
    Doni, Elena (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Gene therapies represent advanced medical tools that aim to fix or improve genes by correcting mutations or making modifications at a specific site. While there are several successful protocols, it remains a ...
  • Hyperferritinemia in liver diseases - diagnosis and controversies 
    Faraj, Shehab (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Ferritin is a protein that plays a crucial role in iron storage and regulation within the body. It is found primarily within cells, particularly in the liver, spleen, bone marrow, and other tissues that store ...
  • Particular features of rheumatoid arthritis onset in the elderly 
    Curilov, Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Rheumatoid arthritis (RA) is a chronic inflammatory disease that can occur at any age, but it can manifest differently in different decades of age. Obvious and significant manifestations of RA occur in those ...
  • Cerebral venous thrombosis after total knee arthroplasty: clinical case report 
    Malai. Sergiu; Dumitrasco, Ana-Maria; Todica, Vlad (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Cerebral venous thrombosis (CVT) represents a rare subtype of stroke involving cerebral veins and sinuses, characterized by challenging diagnosis due to its atypical clinical presentations and low occurrence. ...
  • Acute viral infection as a trigger for DSNMG: a case report 
    Stafi, Vlada; Stavila, Iulia; Tofan, Lucian (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Categorical evidence shows that patients with Acute Respiratory Viral Infections have a higher risk of concurrently developing autoimmune diseases, reflecting phenotypic heterogeneity in MG. The association ...
  • Herpes zoster in patients with HIV/AIDS. Epidemiological, clinical and treatment features 
    Josan, Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Herpes Zoster represents the phenotype, conditioned by the reactivation of the Varicella zoster virus from its latent phase. It manifests itself as viral ganglioneuritis with damage to the intervertebral ...
  • Telomere and telomerase function: safeguarding chromosomal ends and their implications in aging and cancer development 
    Batîr, Mihaela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Telomeres, the protective caps at the ends of linear chromosomes, play a crucial role in maintaining genomic stability and integrity. As cells undergo repeated divisions, telomeres progressively shorten, ...
  • The clinical and immunological features of myasthenia gravis with anti-musk antibodies 
    Țîrdea, Alexei (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Myasthenia gravis is an autoimmune disorder of the neuromuscular junction, caused by autoantibodies synthesized against AChR, MuSK or LRP4. There is also a seronegative form, where antibodies are not detected. ...
  • Role of neurofilament light chain in neurological disease 
    Vasilieva, Irina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Neurofilament light chain (NF-L) is a cytoplasmic protein highly expressed in large-caliber myelinated axons. The degree of axonal damage in a variety of neurological disorders, including inflammatory, ...
  • Benign tumors of the vocal cords. General notions. Epidemiology, etiopathogenesis and treatment 
    Țîbulac, Daniela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Benign vocal lesions are non-malignant growths of abnormal tissue on the vocal cords. The common benign lesions of vocal cord are singer’s nodule, polyps, papilloma, polypoid degeneration (Reinke’s edema) and ...
  • Artificial intelligence involvement in neurosurgery 
    Costin, Antonina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The incorporation of Artificial Intelligence (AI) in medicine involves the application of sophisticated machine learning algorithms to examine vast datasets, encompassing medical and genetic patient data. ...
  • Conduct of patients with cervical pathology 
    Popa, Iulia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The cervix, essential in female reproduction, raises significant concerns regarding precancerous conditions with a significant global and local impact. In the Republic of Moldova, 600-700 women per year are ...
  • Epithelial tissue as a component of the immune system 
    Pila, Gheorghe (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Epithelial tissue is an essential component of the human body, not only for its basic functions such as protection, secretion and absorption, but also for its significant contribution to the immune system. ...
  • The role of virtual and augmented reality in neuroscience 
    Saranciuc, Ruslana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Virtual (VR) and augmented reality(AR) are new tools that are already being successfully used in neurorehabilitation and therapy. But these technologies are still perceived by some experts with skepticism. ...
  • Cystic fibrosis: current therapeutic targets based on symptoms occurred due to specific CFRT gene mutations 
    Caraman, Daniela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Cystic fibrosis (henceforth CF) is autosomal recessive disease involving mucus and sweat producing cells affecting multiple organs with lungs most severely affected leading to death in 90% of patients . A ...
  • Treatment of generalized nodal non-Hodgkin's lymphomas 
    Dunas, Adriana; Musteață, Vasile (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Non-Hodgkin's lymphomas (NHL) comprise a diverse group of malignant lymphoid tumors, with multiple distinct histological and immunohistochemical subtypes. Understanding and differentiating these subtypes is ...
  • Prevalence of POAF following cardiac surgery and comparative study on the preferred treatment modalities 
    Joy, Anugrah (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Postoperative atrial fibrillation (POAF) is a common arrhythmia after cardiac surgery, with an incidence ranging from 10-65%. It is more common in older patients and noncardiac surgery patients. POAF usually ...
  • The correct early diagnosis established by the multidisciplinary team is the key to success in the treatment of the post-myocardial infarction patient, complicated with renal infarction and pneumonia-infarction 
    Gobjila, Ion (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. According to the ESC guideline for the management of Acute Coronary Syndrome (ACS) it meets a spectrum of conditions, from symptoms and signs, with or without 12-lead ECG changes and with or without positive ...
  • Epidemiological and clinical aspects of indolent extranodal non-Hodgkin's lymphoma in the Republic of Moldova 
    Josanu, Marina; Dudnic, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Non-Hodgkin's lymphoma (NHL)-lymphoproliferative tumors that are histologically and biologically heterogeneous. The most common subtypes of indolent NHL being follicular lymphoma (FL), marginal zone lymphoma ...
  • Impact of chronic obstructive pulmonary disease on quality of life 
    Lupu, Liliana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Chronic Obstructive Pulmonary Disease (COPD) is the leading cause of morbidity and mortality worldwide. According to the World Health Organization, globally, COPD is the third leading cause of death, accounting ...

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