MedEspera 2024: Recent submissions

  • Navigating the challenges of short Bowel syndrome 
    Cucu, Alexandra-Gabriela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Short bowel syndrome (SBS) is a rare condition characterized by malabsorption of macronutrients, micronutrients, electrolytes, and water following extensive resection or loss of a significant portion of the ...
  • Etiopathogenetic frontiers of trophoblastic neoplasms: a comprehensive review 
    Zingan, Mihaela (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Trophoblastic neoplasms, a heterogeneous group of gestational trophoblastic diseases, present intricate challenges in deciphering their etiological and pathogenetic underpinnings. While these rare gestational ...
  • Study of the chemotherapy treatment of patients with malignant melanoma with distant metastases during the years 2018-2022 within the IMSPIO of the Republic of Moldova 
    Miaun, Cătlin-Cătălina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Malignant melanoma is one of the most aggressive malignant tumors in the world, and the incidence and mortality increase annually due to the multitude of risk factors and insufficient information among the ...
  • Etiology and diagnostic particulars of benign ovarian tumors 
    Ambrosiv, Ana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. According to the official data, the most widespread diseases of the reproductive system, at women of reproductive age, are ovarian tumors. The research results address the etiology and diagnosis of benign ...
  • Histological and immunohistochemical particularity of pectoralis gland cancer. Retrospective study in Oncology Institute from Moldova (2017-2022) 
    Ameena, Jasmin Rahman Nareekode Paramba Mujeeb Rahman (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Pectoral Gland cancer in men is rare and occurs in 0.5-1% of all breast cancers. The risk factors are various, but the most common are the genetic mutation of BRCA2, familial history, and hormone disbalance. ...
  • Malignant tumors in children: epidemiological and evolutionary aspects 
    Rusu, Maria (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. The spectrum of malignant tumors in children differs significantly from that of adults. Whereas adult tumors are the result of cell differentiation from a mature tissue histologically, pediatric tumors originate ...
  • Surgical treatment of cutaneous malignant melanoma 
    Pușcaș, Nina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Cutaneous malignant melanoma (MMC) represents a current problem of clinical oncology, the cause being its biological particularities, aggressive evolution and early metastasis. The actuality is determined by ...
  • Role of neoadjuvant chemotherapy in locally advanced gastric cancer 
    Cazacu, Oleg (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Locally advanced gastric cancer (LAGC) remains a very aggressive condition, being the 5th most common malignant tumor worldwide and the 4th leading cause of death, surgical intervention remaining as the main ...
  • A case report of single ventricle - peculiarities of evolution in a 8-month-old child 
    Gorbatenco, Daniela; Mindru, Elena (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Single ventricle is a type of malformation when the heart has both normally developed atria, but they open into a single ventricular chamber. The disease has a multifactorial nature in which both genetic and ...
  • Transthyretin cardiac amyloidosis and bone scintigraphy: state of the art detection in rare diseases 
    Asavei, Letiția; Cârciumaru, Marius; Ciocoiu-Bunilă, Ioan Vlad; Gorea, Diana Valentina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Transthyretin cardiac amyloidosis (ATTR-ca) is a rare protein deposition disease characterized by the accumulation of amyloid in the myocardium altering its function. Diagnosing it has proven to be a challenge ...
  • Burden of bullying for mental health state in children and adolescents 
    Alexeev, Tatiana (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. School bullying constitutes a complex and alarming societal issue that negatively impacts students worldwide. The term "bullying" refers to repeated behaviors of intimidation, aggression, or verbal and physical ...
  • The role of genetic aspects in pathophysiology of cushing syndrome 
    Pascari, Anastasia (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Cushing's syndrome is considered a rare disease with an incidence of 0.2– 0.5 million population per year, with an average age of 41 years at diagnosis and 1–2 cases per 100,000 population per year. As known, ...
  • The role of NO and H2S in circulatory homeostasis regulation and dysfunction 
    Eremia, Alexandru (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Modern concept corroborates vascular endothelium as a crucial pillar regarding the control of a lot of vascular derived functions in circulatory homeostasis, such as: basal vascular tone and blood pressure, ...
  • Advancing Parkinson's disease management: novel strategies and therapeutic innovations 
    Budianu, Cătălina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Parkinson's disease is a long-term neurodegenerative condition of the central nervous system that mainly affects the control of voluntary movements due to the gradual degeneration of dopaminergic neurons ...
  • Contemporary approaches to the treatment of frontotemporal dementia 
    Iarovoi, Alexandru (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Frontotemporal dementia or FTD relates to a group of diseases that are caused by neuronal degeneration. FTD is mainly of genetic etiology, due to mutations occurring in specific genes, and may be transmitted ...
  • Mesenchymal stem cell-derived exosomes and their antineoplastic potential 
    Louka, George (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Mesenchymal stem cells (MSC) are pluripotent cell types derived from mesenchyme able to differentiate and proliferate into a variety of tissues. Exosomes derived from MSC exhibit a round morphology (40-160 ...
  • Gene therapy for adenosine deaminase severe combined immunodeficiency (ADA-SCID) 
    Bogdanov, Alan (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. About 1 in 500,000 people are born with severe combined immunodeficiency (SCID). The adenosine deaminase variant is a fatal inborn error of purine metabolism. Accumulation of adenosine and deoxyadenosine ...
  • Combination of beta-blockers with ace inhibitors in the treatment of hypertension in patients with cardiac comorbidities 
    Ticlenco, Teodorina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Approximately 1.28 billion people worldwide are estimated to have hypertension, and it can either promote or accompany other cardiac comorbidities. The combination of betablockers with angiotensin-converting ...
  • Mechanisms of drug-induced nephrotoxicity 
    Iapara, Olga (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Drug-induced nephrotoxicity or drug-induced renal disease (DRID) is a common clinical problem. It has been reported that the incidence of drug-induced renal disease in adults can range from 14-26% to 66% ...
  • Drugs of choice in hypertensive emergency associated with acute aortic dissection 
    Prijilevschi, Cristina (Instituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldova, 2024)
    Introduction. Acute aortic dissection is a hypertensive emergency that requires an immediate reduction of blood pressure (BP) by administering intravenous drug therapy. Diligent control of BP is the most crucial in order ...

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