Institutional Repository in Medical Sciences
(IRMS – Nicolae Testemițanu SUMPh)

Browsing „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025 by Issue Date

Browsing „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025 by Issue Date

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  • The influence of calcitriol on the Warburg efect in cancer 
    Cojoc, Daniela; Sardari, Veronica; Munteanu, Roman; Stratulat, Silvia; Pantea, Valeriana; Tagadiuc, Olga (CEP Medicina, 2025)
    Background. Cancer cells undergo changes in the tumorigenic process through the Warburg effect, also known as aerobic gligolysis. The Warburg effect ensures the conversion of glucose to pyruvate and subsequently to lactate ...
  • The role of vitamin D in the Wnt/β-catenin signaling pathway 
    Cojoc, Daniela; Sardari, Veronica (CEP Medicina, 2025)
    Background. The Wnt/β-catenin signaling pathway is a complex system involved in immune homeostasis, tissue regeneration, and various physiological processes. Aberrant activation of the signaling pathway, driven by genetic ...
  • LUCAs testimonies: cell evolution 
    Cotelea-Baligari, Ana; Șaptefrați, Lilian (CEP Medicina, 2025)
    Introduction. The last universal common ancestor (LUCA) represents a pivotal stage in cell evolution, serving not only as the bridge between prebiotic chemistry and modern biological systems but also providing insights ...
  • Why is “brainwashing” necessary? Histophysiology investigation 
    Crețu, Maxim; Șaptefrați, Lilian (CEP Medicina, 2025)
    Background. The glymphatic system represents the indispensable mechanism for maintaining cerebral homeostasis, facilitating the drainage of cerebrospinal fluid (CSF) and the direct evacuation of neurotoxic metabolites. ...
  • The influence of vitamin D on metabolic syndrome 
    Condrea, Daniela; Protopop, Svetlana (CEP Medicina, 2025)
    Introduction. Metabolic syndrome (MS) is a major public health concern, characterized by a combination of central obesity, dyslipidemia, hypertension, and insulin resistance. In recent years, increasing evidence has ...
  • Cancer stem cells and tumor microenvironment: implications for therapy resistance and novel strategies 
    Colibaba, Vasile; Sardari, Veronica (CEP Medicina, 2025)
    Background. Cancer stem cells (CSCs) represent a distinct subpopulation of tumors, characterized by self-renewal capacity and multilineage differentiation potential. These cells interact dynamically with the tumor ...
  • Clinical case: the impact of renal transplantation in the patient with renal pathology and gout 
    Cornea, Cornelia; Ceban, Emil; Rotaru, Larisa; Groppa, Liliana; Sasu, Boris; Tagadiuc, Olga; Romanciuc, Grigore; Timbalari, Tatiana; Buga, Diana; Nacu, Viorel (CEP Medicina, 2025)
    Introduction:Renal transplantation is a radical treatment option for patients with chronic kidney disease (CKD), significantly impacting those with coexisting renal pathology, such as gout. The use of immunosuppressants ...
  • The prospects of selective JAK inhibitors in hematopoietic stem cells transplantation 
    Cozma, Octavian; Tonofa, Maria; Timercan, Tatiana (CEP Medicina, 2025)
    Introduction. Hematopoietic stem cell transplantation (HSCT) represents a life-saving therapy for hematological malignancies, but its efficacy is often compromised by graft-versus-host disease (GVHD). GVHD remains a major ...
  • The role of miR-152-5p in renal transplantation 
    Cojocaru, Madalina; Ambros, Ala (CEP Medicina, 2025)
    Introduction. miR-152-5p is a microRNA involved in the regulation of gene expression at the posttranscriptional level, primarily expressed in hematopoietic cells. It impacts the regulation of genes involved in T cells and ...
  • Neuroprotective effects of ethanolic extracts from Solanum macrocarpon in a zebrafish model of scopolamine-induced Alzheimer's disease-related dementia 
    Brînza, Ion; Guliev, Corina A.; Oluwabukola Oresanya, Ibukun; Nazli Gok, Hasya; Erdogan Orhan, Ilkay; Hrițcu, Lucian (CEP Medicina, 2025)
    Introduction. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and oxidative stress. Natural bioactive compounds with antioxidant and neuroprotective properties have ...
  • Correlation between CD45 expression and clinical-pathological variables in invasive ductal breast carcinoma associated with type 2 diabetes mellitus 
    Brînza, Dumitru (CEP Medicina, 2025)
    Introduction. This study investigates the correlation between CD45 expression and clinicalpathological variables in invasive ductal breast carcinoma associated with type 2 diabetes mellitus. CD45, an immune regulator, was ...
  • Cardiorenal syndrome and cellular therapeutic perspectives: risk factor identification for targeted interventions 
    Tonofa, Maria; Purteanu, Lilia; Benescu, Irina; Cozma, Octavian; Grib, Livi (CEP Medicina, 2025)
    Introduction. Cardiorenal syndrome (CRS) is a complex pathological condition that highlights the bidirectional relationship between heart failure and chronic kidney disease. This interdependence is driven by multiple ...
  • Specific features of the facial nerve trunk 
    Babuci, Angela; Zorina, Zinovia; Bendelic, Anastasia; Ostahi, Nadia; Botnari, Tatiana; Botnaru, Doina; Lehtman, Sofia; Motelica, Gabriela; Nastas, Liliana; Calancea, Sergiu (CEP Medicina, 2025)
    Introduction: The facial nerve trunk (FNT) is vulnerable to iatrogenic injures in surgery of the retromandibular region, particularly in mastoidectomy. Variation of the FNT number, topography and course increase the risk ...
  • Stem cells in regenerative dentistry: actualities and future directions 
    Țurcan, Paula; Capcelea, Svetlana (CEP Medicina, 2025)
    Introduction. Stem cells are pluripotent cells capable of differentiating into various specialized cell types, making them a promising tool in regenerative dentistry. Their potential to regenerate different parts of the ...
  • Endocrine disruptors - a current problem for the human body 
    Zavtoni, Mariana; Miron, Inga; Bernic, Vladimir; Corețchi, Roman (CEP Medicina, 2025)
    Introduction. Endocrine disruptors are chemical substances that cause adverse effects in an organism or its offspring, leading to morphological and physiological changes and contributing to the deterioration of functional ...
  • Variability of the paired visceral branches of the abdominal aorta 
    Botnari, Tatiana; Babuci, Angela; Zorina, Zinovia; Catereniuc, Ilia; Botnaru, Doina; Ostahi, Nadia (CEP Medicina, 2025)
    Introduction: The demand for an individualized approach in interventional surgery of abdominal cavity organs has recently increased. Due to various surgical techniques and large number of surgeries, including kidney ...
  • Anatomical variability of the deep femoral artery 
    Botnaru, Doina; Zorina, Zinovia; Babuci, Angela; Catereniuc, Ilia; Botnari, Tatiana (CEP Medicina, 2025)
    Introduction: The deep femoral artery (DFA) serves as a crucial „turning point” between collateral circulation of the pelvis and that of the lower limb (LL), playing a determinant role not only in femoropopliteal axis ...
  • Current events in liver transplatology 
    Zavtoni, Ana-Maria; Harea, Gheorghe (CEP Medicina, 2025)
    Background. Liver transplantation is a surgical procedure that involves removing a diseased liver and replacing it with a healthy liver from another person, called a donor. This procedure is used when the liver is unable ...
  • Bacterial resistance in urinary tract infections in kidney transplant patients: literature review 
    Bacinschi, Nicolae; Dabija, Maria; Mihalachi-Anghel, Maria; Spinosu, Galina (CEP Medicina, 2025)
    Introduction. Urinary tract infections are the most common complication in renal transplant patients and a major cause of morbidity, hospitalization and mortality. The incidence of urinary tract infections varies widely ...
  • The role of mesenchymal stem cell-derived extracellular vesicles in cardiac repair 
    Bogdanov, Alan; Badalyan, Albert; Babuci, Angela (CEP Medicina, 2025)
    Introduction: Cardiovascular diseases remain the predominant cause of global morbidity and mortality. Traditional treatments, including therapeutical and surgical approaches, primarily address symptoms rather than ...

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