Institutional Repository in Medical Sciences
(IRMS – Nicolae Testemițanu SUMPh)

Browsing „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025 by Issue Date

Browsing „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025 by Issue Date

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  • Cardiorenal syndrome and cellular therapeutic perspectives: risk factor identification for targeted interventions 
    Tonofa, Maria; Purteanu, Lilia; Benescu, Irina; Cozma, Octavian; Grib, Livi (CEP Medicina, 2025)
    Introduction. Cardiorenal syndrome (CRS) is a complex pathological condition that highlights the bidirectional relationship between heart failure and chronic kidney disease. This interdependence is driven by multiple ...
  • Exploring the impact of mesenchymal stem cells on chronic wound repair 
    Țarălungă, Maxim; Nacu, Viorel; Țarălungă, Tatiana; Bour, Alin (CEP Medicina, 2025)
    Introduction: Chronic wounds are a significant medical concern, especially among the aging population, with conditions like diabetic ulcers, and venous leg ulcers being prominent examples. These wounds often fail to heal ...
  • Stem cells in regenerative dentistry: actualities and future directions 
    Țurcan, Paula; Capcelea, Svetlana (CEP Medicina, 2025)
    Introduction. Stem cells are pluripotent cells capable of differentiating into various specialized cell types, making them a promising tool in regenerative dentistry. Their potential to regenerate different parts of the ...
  • Endocrine disruptors - a current problem for the human body 
    Zavtoni, Mariana; Miron, Inga; Bernic, Vladimir; Corețchi, Roman (CEP Medicina, 2025)
    Introduction. Endocrine disruptors are chemical substances that cause adverse effects in an organism or its offspring, leading to morphological and physiological changes and contributing to the deterioration of functional ...
  • Review of rodent hypertension glaucoma models 
    Țarălungă, Tatiana; Iacubițchii, Maria; Paduca, Ala; Nacu, Viorel (CEP Medicina, 2025)
    Background: Hypertension is a major risk factor for glaucoma, a leading cause of irreversible blindness. Elevated intraocular pressure (IOP) is central to glaucoma pathology, often causing optic nerve damage and retinal ...
  • Current events in liver transplatology 
    Zavtoni, Ana-Maria; Harea, Gheorghe (CEP Medicina, 2025)
    Background. Liver transplantation is a surgical procedure that involves removing a diseased liver and replacing it with a healthy liver from another person, called a donor. This procedure is used when the liver is unable ...
  • Liver transplantation from a living-donor 
    Stoian, Carolina (CEP Medicina, 2025)
    Introduction. Living-donor liver transplantation (LDLT) is vital for end-stage liver disease and acute liver failure, alleviating organ shortages and reducing wait times. In the Republic of Moldova, where deceased-donor ...
  • Fecal microbiota transplantation in cirrhosis: a microbiome-based therapeutic revolution 
    Marcu, Beatrice; Sardari, Veronica (CEP Medicina, 2025)
    Introduction. The gut microbiota, as well as the gut-liver axis, play a significantly important role in the fibrosis process. As fibrosis progresses to cirrhosis, it further worsens the microbiota, creating a vicious cycle ...
  • Stem cell transplantation in bipolar disorder: exploring regenerative treatment approaches 
    Sîrbu, Mariana; Bologan, Alina (CEP Medicina, 2025)
    Introduction: Bipolar disorder (BD) is a chronic neuropsychiatric condition affecting over 1% of the global population, characterized by alternating episodes of mania and depression. Traditional pharmacological treatments, ...
  • The influence of calcitriol on the Warburg efect in cancer 
    Cojoc, Daniela; Sardari, Veronica; Munteanu, Roman; Stratulat, Silvia; Pantea, Valeriana; Tagadiuc, Olga (CEP Medicina, 2025)
    Background. Cancer cells undergo changes in the tumorigenic process through the Warburg effect, also known as aerobic gligolysis. The Warburg effect ensures the conversion of glucose to pyruvate and subsequently to lactate ...
  • The role of vitamin D in the Wnt/β-catenin signaling pathway 
    Cojoc, Daniela; Sardari, Veronica (CEP Medicina, 2025)
    Background. The Wnt/β-catenin signaling pathway is a complex system involved in immune homeostasis, tissue regeneration, and various physiological processes. Aberrant activation of the signaling pathway, driven by genetic ...
  • LUCAs testimonies: cell evolution 
    Cotelea-Baligari, Ana; Șaptefrați, Lilian (CEP Medicina, 2025)
    Introduction. The last universal common ancestor (LUCA) represents a pivotal stage in cell evolution, serving not only as the bridge between prebiotic chemistry and modern biological systems but also providing insights ...
  • Why is “brainwashing” necessary? Histophysiology investigation 
    Crețu, Maxim; Șaptefrați, Lilian (CEP Medicina, 2025)
    Background. The glymphatic system represents the indispensable mechanism for maintaining cerebral homeostasis, facilitating the drainage of cerebrospinal fluid (CSF) and the direct evacuation of neurotoxic metabolites. ...
  • Adipose tissue in chest region and its impact on the condition of various organs 
    Hacina, Tamara; Darwich, Jasmin (CEP Medicina, 2025)
    Introduction. The presence of the adipose tissue in the chest region might be linked to many pathological conditions meanwhile it can be physiological in many cases. A comprehensive assessment requires a morphological ...
  • Liver transplantation in Wilson’s disease 
    Rotaru, Ludmila (CEP Medicina, 2025)
    Background. Wilson’s disease is a rare genetic disorder caused by excessive copper accumulation in the body, particularly in the liver and brain. In severe cases, where the disease leads to liver failure, liver transplantation ...
  • The influence of vitamin D on metabolic syndrome 
    Condrea, Daniela; Protopop, Svetlana (CEP Medicina, 2025)
    Introduction. Metabolic syndrome (MS) is a major public health concern, characterized by a combination of central obesity, dyslipidemia, hypertension, and insulin resistance. In recent years, increasing evidence has ...
  • Cancer stem cells and tumor microenvironment: implications for therapy resistance and novel strategies 
    Colibaba, Vasile; Sardari, Veronica (CEP Medicina, 2025)
    Background. Cancer stem cells (CSCs) represent a distinct subpopulation of tumors, characterized by self-renewal capacity and multilineage differentiation potential. These cells interact dynamically with the tumor ...
  • Clinical case: the impact of renal transplantation in the patient with renal pathology and gout 
    Cornea, Cornelia; Ceban, Emil; Rotaru, Larisa; Groppa, Liliana; Sasu, Boris; Tagadiuc, Olga; Romanciuc, Grigore; Timbalari, Tatiana; Buga, Diana; Nacu, Viorel (CEP Medicina, 2025)
    Introduction:Renal transplantation is a radical treatment option for patients with chronic kidney disease (CKD), significantly impacting those with coexisting renal pathology, such as gout. The use of immunosuppressants ...
  • The prospects of selective JAK inhibitors in hematopoietic stem cells transplantation 
    Cozma, Octavian; Tonofa, Maria; Timercan, Tatiana (CEP Medicina, 2025)
    Introduction. Hematopoietic stem cell transplantation (HSCT) represents a life-saving therapy for hematological malignancies, but its efficacy is often compromised by graft-versus-host disease (GVHD). GVHD remains a major ...
  • Nanocarriers that may bypass the blood-brain barrier 
    Croitoru, Dan; Todica, Vladislav; Andronachi, Victor; Andrusca, Alexandru; Visnevschi, Sergiu (CEP Medicina, 2025)
    Introduction: The blood-brain barrier (BBB), blood-cerebrospinal fluid barrier (BCSFB) and bloodbrain tumour barrier (BBTB) are regarded as potential barriers for drug delivery. Nanocarriers are designed in order to bypass ...

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