Institutional Repository in Medical Sciences
(IRMS – Nicolae Testemițanu SUMPh)

Browsing „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025 by Issue Date

Browsing „Cells and tissues transplantation. Actualities and perspectives. The 3rd edition” dedicated to the 80th anniversary of the founding of Nicolae Testemitanu State University of Medicine and Pharmacy. Chisinau, March 21-22, 2025 by Issue Date

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  • Stem cell transplantation in bipolar disorder: exploring regenerative treatment approaches 
    Sîrbu, Mariana; Bologan, Alina (CEP Medicina, 2025)
    Introduction: Bipolar disorder (BD) is a chronic neuropsychiatric condition affecting over 1% of the global population, characterized by alternating episodes of mania and depression. Traditional pharmacological treatments, ...
  • Exploring the impact of mesenchymal stem cells on chronic wound repair 
    Țarălungă, Maxim; Nacu, Viorel; Țarălungă, Tatiana; Bour, Alin (CEP Medicina, 2025)
    Introduction: Chronic wounds are a significant medical concern, especially among the aging population, with conditions like diabetic ulcers, and venous leg ulcers being prominent examples. These wounds often fail to heal ...
  • LUCAs testimonies: cell evolution 
    Cotelea-Baligari, Ana; Șaptefrați, Lilian (CEP Medicina, 2025)
    Introduction. The last universal common ancestor (LUCA) represents a pivotal stage in cell evolution, serving not only as the bridge between prebiotic chemistry and modern biological systems but also providing insights ...
  • Why is “brainwashing” necessary? Histophysiology investigation 
    Crețu, Maxim; Șaptefrați, Lilian (CEP Medicina, 2025)
    Background. The glymphatic system represents the indispensable mechanism for maintaining cerebral homeostasis, facilitating the drainage of cerebrospinal fluid (CSF) and the direct evacuation of neurotoxic metabolites. ...
  • Adipose tissue in chest region and its impact on the condition of various organs 
    Hacina, Tamara; Darwich, Jasmin (CEP Medicina, 2025)
    Introduction. The presence of the adipose tissue in the chest region might be linked to many pathological conditions meanwhile it can be physiological in many cases. A comprehensive assessment requires a morphological ...
  • Liver transplantation from a living-donor 
    Stoian, Carolina (CEP Medicina, 2025)
    Introduction. Living-donor liver transplantation (LDLT) is vital for end-stage liver disease and acute liver failure, alleviating organ shortages and reducing wait times. In the Republic of Moldova, where deceased-donor ...
  • Liver transplantation in Wilson’s disease 
    Rotaru, Ludmila (CEP Medicina, 2025)
    Background. Wilson’s disease is a rare genetic disorder caused by excessive copper accumulation in the body, particularly in the liver and brain. In severe cases, where the disease leads to liver failure, liver transplantation ...
  • The influence of vitamin D on metabolic syndrome 
    Condrea, Daniela; Protopop, Svetlana (CEP Medicina, 2025)
    Introduction. Metabolic syndrome (MS) is a major public health concern, characterized by a combination of central obesity, dyslipidemia, hypertension, and insulin resistance. In recent years, increasing evidence has ...
  • Clinical case: the impact of renal transplantation in the patient with renal pathology and gout 
    Cornea, Cornelia; Ceban, Emil; Rotaru, Larisa; Groppa, Liliana; Sasu, Boris; Tagadiuc, Olga; Romanciuc, Grigore; Timbalari, Tatiana; Buga, Diana; Nacu, Viorel (CEP Medicina, 2025)
    Introduction:Renal transplantation is a radical treatment option for patients with chronic kidney disease (CKD), significantly impacting those with coexisting renal pathology, such as gout. The use of immunosuppressants ...
  • The prospects of selective JAK inhibitors in hematopoietic stem cells transplantation 
    Cozma, Octavian; Tonofa, Maria; Timercan, Tatiana (CEP Medicina, 2025)
    Introduction. Hematopoietic stem cell transplantation (HSCT) represents a life-saving therapy for hematological malignancies, but its efficacy is often compromised by graft-versus-host disease (GVHD). GVHD remains a major ...
  • Regenerative approaches for managing percutaneous nephrostomy complications: stem cell and tissue engineering strategies 
    Goras, Valeria; Tanase, Adrian (CEP Medicina, 2025)
    Introduction: Percutaneous nephrostomy (PCN) is a crucial intervention for urinary tract decompression in obstructive uropathy, malignancy, and infection. However, it carries significant risks, including hemorrhage, ...
  • Nanocarriers that may bypass the blood-brain barrier 
    Croitoru, Dan; Todica, Vladislav; Andronachi, Victor; Andrusca, Alexandru; Visnevschi, Sergiu (CEP Medicina, 2025)
    Introduction: The blood-brain barrier (BBB), blood-cerebrospinal fluid barrier (BCSFB) and bloodbrain tumour barrier (BBTB) are regarded as potential barriers for drug delivery. Nanocarriers are designed in order to bypass ...
  • Material design in hard tissue engineering 
    Jian, Mariana; Codrea, Cosmin; Spoiala, Angela; Ficai, Denisa; Nacu, Viorel; Ficai, Anton (CEP Medicina, 2025)
    Introduction: Considering the high incidence and the relatively large amount needed, the overall market share of the bone grafting materials is ~49% of the total field of biomaterials and thus many researchers focused ...
  • Challenges in the treatment of ocular surface pathologies 
    Cușnir, Valeriu; Dumbraveanu, Lilia; Lupan, Valentina; Cociug, Andrian; Procopciuc, Vitalie; Cușnir, Valeriu V.; Balba, Rodica; Bostan, Mihaela; Nacu, Viorel (CEP Medicina, 2025)
    Introduction. Tissue transplantation at the ocular surface for therapeutic, tectonic, reconstructive, or optical purposes is a routine practice among ophthalmic surgeons worldwide. The main ocular surface pathologies ...
  • Novel therapies in osteoarthritis current status and perspectives 
    Labusca, Luminița (CEP Medicina, 2025)
    Osteoarthritis (OA) remains a major contributor to disability worldwide, placing a significant burden on healthcare systems. Current treatment strategies predominantly focus on symptom management rather than halting or ...
  • Neuroprotective effects of ethanolic extracts from Solanum macrocarpon in a zebrafish model of scopolamine-induced Alzheimer's disease-related dementia 
    Brînza, Ion; Guliev, Corina A.; Oluwabukola Oresanya, Ibukun; Nazli Gok, Hasya; Erdogan Orhan, Ilkay; Hrițcu, Lucian (CEP Medicina, 2025)
    Introduction. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and oxidative stress. Natural bioactive compounds with antioxidant and neuroprotective properties have ...
  • The role of endothelins in cancer progression: recent insights and therapeutic opportunities 
    Cazacu, Felicia; Sardari, Veronica; Munteanu, Roman; Rudic, Ciprian; Tagadiuc, Olga (CEP Medicina, 2025)
    Background. Endothelins (ETs) and their receptors (ETAR and ETBR) play a significant role in cancer progression, influencing processes such as proliferation, invasion, and metastasis. The endothelin axis contributes to ...
  • Correlation between CD45 expression and clinical-pathological variables in invasive ductal breast carcinoma associated with type 2 diabetes mellitus 
    Brînza, Dumitru (CEP Medicina, 2025)
    Introduction. This study investigates the correlation between CD45 expression and clinicalpathological variables in invasive ductal breast carcinoma associated with type 2 diabetes mellitus. CD45, an immune regulator, was ...
  • Telomere shortening as a mechanism for the induction of neurodegenetative diseases 
    Casian, Andreea; Sardari, Veronica; Stratulat, Silvia; Munteanu, Roman; Cojoc, Daniela; Tagadiuc, Olga (CEP Medicina, 2025)
    Background. Telomeres are considered the "cellular biological clock" because their length could determine the possible number of cell divisions. Telomerase plays a role in maintaining telomere length. Telomerase ensures ...
  • Nasal permeability in inflammatory rhinosinusal diseases in children 
    Maniuc, Mihail; Danilov, Lucian; Ababii, Polina; Nacu, Viorel; Furculița, Daniel; Bugan, Maria; Crețu, Carolina; Vishnumaya, Sureshan (CEP Medicina, 2025)
    Introduction: Rhinosinusal inflammatory diseases constitute a current problem of contemporary rhinology. Rhinitis, sinusitis seriously affect the physiological functions of the nose, including the most important of them, ...

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